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It is not just the "continuous" methods, such as True Allele and STRmix, that can produce different answers in repeated analyses of identical data. This is also true of the non-continuous method likeLTD.

This is no different to many other scientific procedures, where repeated measurements will produce slightly different answers.
The scientific solution to this variability is to carry out the measurements more than one once.

If you come across a case involving one of these methods, ask the expert - or instruct one - to carry out multiple analyses to check that the "best answer" has been found.

Despite problems, these sophisticated computerised methods are a great advance on the subjective guesses allowed by the Court of Appeal judgment in MDS, Piickering and Dlugosz.